• Zhonghua yi xue za zhi · Jan 2005

    Randomized Controlled Trial Multicenter Study Clinical Trial

    [Curative effect of gabapentin on refractory epilepsy].

    • Guo-Xing Zhu, Mei-Ping Ding, Bo Xiao, De-Xin Wang, De-Sheng Wang, Yi-Zhen Pan, Qing-Chen Zhao, Yang-Fu Pan, Guang-Yu Ma, Zhen Hong, and Chuan-Zhen Lü.
    • Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200040.
    • Zhonghua Yi Xue Za Zhi. 2005 Jan 12; 85 (2): 92-5.

    ObjectiveTo assess the safety and efficacy of gabapentin in treatment of refractory epilepsy.MethodsSixty-six patients with refractory epilepsy were treated with gabapentin 200 mg/d and 72 patients with placebo, totally 138 patients in five hospitals in different cities in China. Double-blind study was performed to observe the times of seizure, and Mini-Mental State Examination (MMSE) and Activities of Daily Life (ADL) assessment were conducted every 4 weeks.ResultsIn comparison with the control group, the seizure times at any time point in the GB group all decreased with significant differences at the 12th and 20th weeks. The significant efficacy rates, with the seizure times decreasing by more than 75%, in the gabapentin group were higher than those in the control group, with significant differences in the 4, 8, 16, and 20th weeks. Both the MMSE scores of the 2 groups were raised with a significant difference between the 2 groups at the 16 weeks. There was no significant difference in ADL between these 2 groups. No serious side effect was found in these 2 groups.ConclusionGabapentin at a dosage of 1200 mg/d is safe and effective in treatment of epilepsy.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…