• Eur. J. Neurol. · Jun 2007

    Randomized Controlled Trial Clinical Trial

    Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia.

    • K H Scheuer, K Svenstrup, P Jennum, B á Rogvi-Hansen, L Werdelin, K Fenger, and J E Nielsen.
    • Department of Neurology, Hillerød Hospital, Denmark. kristin@scheuerhome.dk
    • Eur. J. Neurol. 2007 Jun 1; 14 (6): 663-6.

    AbstractPatients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.

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