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- Aline B Maddux and Ivor S Douglas.
- Division of Pediatric Critical Care, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
- Immunology. 2015 May 1; 145 (1): 1-10.
AbstractImmunologically immature neonates suffer the highest incidence of paediatric sepsis. Postnatal immunological maturation is characterized by a relatively hypo-inflammatory immune response. The mechanisms that differentiate the mature and immature immune responses resemble those that differentiate the hyper- and hypo-inflammatory responses in severe sepsis. Immunological maturational differences likely affect the neonate's ability to mount an appropriate hyper-inflammatory response, a counteractive hypo-inflammatory response, and subsequent return to immune system homeostasis. To better understand the role of the hypo-inflammatory response in paediatric sepsis, we will explore the maturation of the immune system and the effect it may have on the sepsis-induced hypo-inflammatory response.© 2015 John Wiley & Sons Ltd.
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