Evaluation of an optical immunoassay for the rapid detection of

Eur. J. Clin. Microbiol. Infect. Dis. · Apr 2001

Evaluation of an optical immunoassay for the rapid detection of influenza A and B viral antigens.

An optical immunoassay for the rapid detection of influenza types A and B viral antigens, FLU OIA (Biostar, USA), was prospectively compared with antigen detection methods and cell culture on 400 respiratory specimens during an influenza outbreak that occurred in Switzerland in 1998/1999. The FLU OIA had an overall sensitivity of 64.4% (95%CI, 56.3-71.7%) and a specificity of 94.9% (95%CI, 89.8-97.7%). Using specimens from pediatric and adolescent patients, the sensitivity obtained (71.8%; 95%CI, 61.7-80%) was different than that achieved with specimens from adult patients (51.4%; 95%CI, 36.5-65%) (P=0.004). The results show that rapid diagnostic tests with higher sensitivity and specificity for the detection of influenza virus are needed.

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- D Schultze, Y Thomas, and W Wunderli.
- Department of Virology, Institute for Clinical Microbiology and Immunology, St. Gallen, Switzerland. detlev.schultze@gd-ikmi.sg.ch
- Eur. J. Clin. Microbiol. Infect. Dis. 2001 Apr 1; 20 (4): 280-3.
AbstractAn optical immunoassay for the rapid detection of influenza types A and B viral antigens, FLU OIA (Biostar, USA), was prospectively compared with antigen detection methods and cell culture on 400 respiratory specimens during an influenza outbreak that occurred in Switzerland in 1998/1999. The FLU OIA had an overall sensitivity of 64.4% (95%CI, 56.3-71.7%) and a specificity of 94.9% (95%CI, 89.8-97.7%). Using specimens from pediatric and adolescent patients, the sensitivity obtained (71.8%; 95%CI, 61.7-80%) was different than that achieved with specimens from adult patients (51.4%; 95%CI, 36.5-65%) (P=0.004). The results show that rapid diagnostic tests with higher sensitivity and specificity for the detection of influenza virus are needed.

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Evaluation of an optical immunoassay for the rapid detection of influenza A and B viral antigens.

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