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Anesthesia and analgesia · Nov 2010
Opioid-induced preconditioning is dependent on caveolin-3 expression.
- Yasuo M Tsutsumi, Yoshitaka Kawaraguchi, Ingrid R Niesman, Hemal H Patel, and David M Roth.
- Department of Anesthesiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. tsutsumi@clin.med.tokushima-u.ac.jp
- Anesth. Analg. 2010 Nov 1; 111 (5): 1117-21.
AbstractWe tested the hypothesis that caveolin-3 (Cav-3) is essential for opioid-induced preconditioning in vivo. Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a δ-selective opioid agonist, or naloxone, a nonselective opioid antagonist. Controls were protected from I/R injury by SNC. No protection was produced by SNC in Cav-3 knockout mice. Cav-3 overexpressing mice showed innate protection from I/R compared with controls that was abolished by naloxone. Our results show that opioid-induced preconditioning is dependent on Cav-3 expression and that endogenous protection in Cav-3 overexpressing mice is opioid dependent.
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