• Acta Anaesthesiol Scand · Jul 2005

    Nociceptin system does not affect MAC of volatile anaesthetics.

    • S Himukashi, Y Miyazaki, H Takeshima, S Koyanagi, K Mukaida, T Shichino, H Uga, and K Fukuda.
    • Department of Anaesthesia, Kyoto University Hospital, Kyoto, Japan. himukash@kuhp.kyoto-u.ac.jp
    • Acta Anaesthesiol Scand. 2005 Jul 1; 49 (6): 771773771-3.

    BackgroundNociceptin is the endogenous agonist of the opioid receptor-like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics. As nociceptin has been reported to be involved in modulating pain mechanisms and stress responses, it is possible that the activity of the nociceptin system affects the anaesthetic potency of general anaesthetics. To address this possibility, we investigated the minimum alveolar concentrations (MACs) of various volatile anaesthetics in nociceptin receptor knockout mice (NOP-/-) and wild-type mice (NOP+/+).MethodsWe used male NOP-/- mice and NOP+/+ mice. MACs for halothane, isoflurane and sevoflurane were determined by the tail-clamp method.ResultsMACs for halothane, isoflurane and sevoflurane in NOP-/- mice were 1.60 (SD 0.06), 1.68 (0.08) and 3.36 (0.07)%, respectively. In NOP+/+ mice, MACs for halothane, isoflurane and sevoflurane were 1.59 (SD 0.07), 1.72 (0.07) and 3.38 (0.09)%, respectively.ConclusionMACs in NOP-/- mice did not significantly differ from those in NOP+/+ mice for halothane, isoflurane and sevoflurane. This result suggests that the nociceptin system does not affect the anaesthetic potency of volatile anaesthetics.

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