• J Parkinsons Dis · Jan 2014

    Review

    An update of the impact of deep brain stimulation on non motor symptoms in Parkinson's disease.

    • Lisa Klingelhoefer, Michael Samuel, K Ray Chaudhuri, and Keyoumars Ashkan.
    • National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital and King's College, Denmark Hill, London, UK Department of Neurology, Technical University Dresden, Dresden, Germany.
    • J Parkinsons Dis. 2014 Jan 1; 4 (2): 289-300.

    AbstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy for patients with Parkinson's disease (PD), especially those with advanced motor complications. The effect of STN DBS on non motor symptoms (NMS) of PD is less well studied. In this article, we review the pertinent literature on the impact of STN DBS on NMS when they co-exist with disabling motor symptoms in PD patients. We also present evidence that the number and the severity of most NMS decrease after STN DBS which can have a major impact on patients' quality of life.

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