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- Frank Musshoff, Ulrike M Stamer, and Burkhard Madea.
- Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany. f.musshoff@uni-bonn.de
- Forensic Sci. Int. 2010 Dec 15; 203 (1-3): 53-62.
AbstractLarge inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can appear at the level of drug metabolizing enzymes (e.g., the cytochrome P450 system), drug transporters, drug targets or other biomarker genes. Pharmacogenetics or toxicogenetics can therefore be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines.Copyright © 2010. Published by Elsevier Ireland Ltd.
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