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Neurobiology of disease · Mar 2014
D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism.
- Carole Hyacinthe, Quentin Barraud, François Tison, Erwan Bezard, and Imad Ghorayeb.
- Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. Electronic address: carole.hyacinthe@u-bordeaux2.fr.
- Neurobiol. Dis. 2014 Mar 1; 63: 20-4.
AbstractBoth excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine macaque monkey. Continuous sleep and wake electroencephalographic monitoring revealed no effect of the selective dopamine D2 receptor agonist quinpirole on EDS, whereas the selective dopamine D1 receptor agonist SKF38393 efficiently alleviated EDS and restored REM sleep to baseline values. The present results question the relevance of abandoning D1 receptor agonist treatment in PD as it might actually improve sleep-related disorders.Copyright © 2013 Elsevier Inc. All rights reserved.
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