• Venkatesh Aiyagari and Michael N Diringer.
• Neurology/Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. aiyagariv@neuro.wustl.edu
• Neurologist. 2002 May 1; 8 (3): 152-62.

BackgroundPatients with large hemispheric strokes frequently develop neurologic deterioration secondary to cerebral edema. Despite supportive care in the intensive care unit and traditional forms of therapy for cerebral edema, they have a high morbidity and mortality. New forms of therapy are being investigated to improve outcome in these patients.Review SummaryThis article begins with a discussion of the clinical and radiologic features of large hemispheric strokes. The role of increased intracranial pressure in neurologic deterioration and the predictors of outcome in these patients are reviewed. The various therapeutic options for management of cerebral edema in these patients, including the role of osmotic therapy, hypothermia, and hemicraniectomy, are explored.ConclusionsNeurologic deterioration in patients with large hemispheric strokes necessitates admission to the intensive care unit for management of the airway, blood pressure, and cerebral edema. New promising therapies, such as hemicraniectomy and hypothermia, need to be further evaluated to define their role in the management of these patients.

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