• Vanda Faria, Nathalie Erpelding, Alyssa Lebel, Adriana Johnson, Robert Wolff, Damien Fair, Rami Burstein, Lino Becerra, and David Borsook.
• aCenter for Pain and the Brain, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA bDepartment of Psychology, Uppsala University, Uppsala, Sweden cChronic Headache Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA dDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA Departments of eBehavioral Neuroscience and fPsychiatry, School of Medicine, Oregon Health and Science University, Portland, OR, USA gDepartment of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
• Pain. 2015 Nov 1; 156 (11): 2212-21.

AbstractThe prevalence of migraine has an exponential trajectory that is most obvious in young females between puberty and early adulthood. Adult females are affected twice as much as males. During development, hormonal changes may act on predetermined brain circuits, increasing the probability of migraine. However, little is known about the pediatric migraine brain and migraine evolution. Using magnetic resonance imaging, we evaluated 28 children with migraine (14 females and 14 males) and 28 sex-matched healthy controls to determine differences in brain structure and function between (1) females and males with migraine and (2) females and males with migraine during earlier (10-11 years) vs later (14-16 years) developmental stages compared with matched healthy controls. Compared with males, females had more gray matter in the primary somatosensory cortex (S1), supplementary motor area, precuneus, basal ganglia, and amygdala, as well as greater precuneus resting state functional connectivity to the thalamus, amygdala, and basal ganglia and greater amygdala resting state functional connectivity to the thalamus, anterior midcingulate cortex, and supplementary motor area. Moreover, older females with migraine had more gray matter in the S1, amygdala, and caudate compared to older males with migraine and matched healthy controls. This is the first study showing sex and developmental differences in pediatric migraineurs in brain regions associated with sensory, motor, and affective functions, providing insight into the neural mechanisms underlying distinct migraine sex phenotypes and their evolution that could result in important clinical implications increasing treatment effectiveness.

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