• J. Pharm. Pharmacol. · May 2013

    Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.

    • Liliana García-Hernández, Gabriel Navarrete-Vázquez, María Eva González-Trujano, Francisco Javier López-Muñoz, and Myrna Déciga-Campos.
    • Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados Sede Sur.
    • J. Pharm. Pharmacol. 2013 May 1; 65 (5): 689-96.

    ObjectivesThe purpose of this study was to assess the antinociceptive and antihyperalgesic effects of a lidocaine analogue N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA).MethodsThe structure of LIA was established by elemental analysis and compatible IR, (1) H NMR, (13) C NMR, and spectral data. Nociceptive and hyperalgesic activity were evaluated in normoglycaemic and streptozocin-induced diabetic rats using the formalin test. Formalin-evoked flinching, an indication of nociception and hyperalgesia, was increased in diabetic rats (using 0.5% formalin) compared with nondiabetic rats (using 1% formalin).Key FindingsLocal administration of LIA into the dorsal surface of the right hind paw (0.18-5.6 mg per paw) significantly reduced the formalin-induced nociceptive and hyperalgesic behaviour of nondiabetic and diabetic rat. The antinociceptive effect of LIA was higher than that of lidocaine injection, furthermore this effect was higher than that of gabapentin.ConclusionsLIA may have potential as a treatment for diabetic hyperalgesia. Further investigations of the antinociceptive mechanisms and the safety of this new compound are necessary.© 2013 The Authors. JPP © 2013 Royal Pharmaceutical Society.

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