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Pediatric pulmonology · Jan 1991
Cold air challenge of airway reactivity in children: a correlation of transcutaneously measured oxygen tension and conventional lung functions.
- E Eber, E M Varga, and M S Zach.
- Department of Pediatrics, University of Graz, Austria.
- Pediatr. Pulmonol. 1991 Jan 1; 10 (4): 273-7.
AbstractFor pharmacological challenges, a correlation between the induced changes of the transcutaneously measured oxygen tension (PtcO2) and of conventional pulmonary function tests (PFTs) has been documented. We performed a 4-minute cold air challenge (CACh) in 17 children with bronchial asthma under continuous monitoring of PtcO2, and correlated observed changes with CACh-induced alterations of conventional PFTs. PtcO2 decreased significantly with CACh (from 86 +/- 10 mmHg to 66 +/- 14 mmHg, P less than 0.001), but returned to near-baseline within the next 30 minutes. PFTs changed with a similar pattern; the closest correlation was found between the CACh-induced fall of PtcO2 and Delta-FEV1 (r = 0.833, P less than 0.001). Changes of FVC, PEF, and Vmax50 correlated significantly as well. PtcO2 can complement or substitute for conventional PFTs in assessing the response to CACh in children.
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