• Minerva anestesiologica · Mar 2017

    Biological markers of injury-induced immunosuppression.

    • Christelle Rouget, Thibaut Girardot, Julien Textoris, Guillaume Monneret, Thomas RIMMELé, and Fabienne Venet.
    • BioMérieux, Joint Research Unit, Hospices Civils de Lyon, BioMérieux, Hôpital Edouard Herriot, Lyon, France - fabienne.venet@chu-lyon.fr.
    • Minerva Anestesiol. 2017 Mar 1; 83 (3): 302 - 314.

    AbstractSevere injuries such as severe sepsis, burn, trauma and major surgery lead to an overlapping development of pro- and anti- inflammatory responses. It is now well established that these injuries are associated with the secondary development of immune suppression, which results in significant morbidity and mortality. Recent data suggest that immunostimulatory drugs might prevent these complications. However, intensive care patients are heterogeneous, making patient stratification essential for a targeted treatment. In the present review, we discuss potential biomarkers of injury-induced immunoparalysis, mainly focusing on these that have been associated with poor outcome in various clinical settings. We namely present clinical data on monocyte human leukocyte antigen DR, lymphopenia, PD-1/PD-L1 and transcriptomic approach.

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