• K Javorka, V Kulisek, V Demidov, V Gecelovská, and L Sutarík.
• Katedra fyziológie LFUK v Martine, Slovakia.
• Bratisl Med J. 1993 Apr 1; 94 (4): 204-8.

AbstractThe effect of high frequency (f = 300.min-1) modulated continuous positive airway pressure (CPAP) (0.49 kPa) was compared with that of CPAP without modulation (0.49 kPa) in 24 anesthetized rabbits in experimental respiratory distress syndrome (RDS) and pulmonary edema. RDS was induced by single excessive lavage of the lung on using the impulse and expulse effect of high frequency jet ventilation. Pulmonary edema was elicited by i.v. administration of a mixture of fatty acids. Decreased dynamic compliance of the lung and increased respiration work and rate were recorded both in experimental RDS and pulmonary edema. In RDS paO2 was reduced and paCO2 increased. In pulmonary edema, despite diminished respiration volume, ventilation was enhanced by the higher respiration rate and both paO2 and paCO2 were reduced. Application of CPAP resulted in normalization of blood gases. Modulated CPAP, compared to CPAP without modulation, further decreased paCO2 and increased paO2. The results obtained in experimental models of RDS and pulmonary edema in rabbits show the beneficial effect of high frequency modulated CPAP by pressure oscillation on values of blood gas tension.

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