• Int J Gynaecol Obstet · Jul 1992

    Interval to delivery in high-risk patients: do tocolytic agents really work?

    • J C Morrison, J R Allbert, R C Floyd, C S Bale, C H Lou, and K S Gookin.
    • Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
    • Int J Gynaecol Obstet. 1992 Jul 1; 38 (3): 189-93.

    AbstractSome question whether tocolytic drugs reduce uterine activity and prolong gestation. The interval from discontinuance of tocolytics until spontaneous labor and delivery in patients (n = 69) with documented preterm labor (PTL) versus subjects receiving prophylactic tocolytic therapy (n = 41) was studied. Women with documented PTL delivered sooner after cessation of tocolytics (6.1 +/- 6.9 days) than control (C) patients (14.7 +/- 10.8 days, P less than 0.001). Also, 28 of the 69 (41%) patients in the PTL group delivered within 24 h of discontinuation of tocolysis compared to 4 (10%) in the C group (P less than 0.0004). We conclude that tocolytic therapy for documented preterm labor suppresses uterine activity and when these agents are discontinued, contractions return and labor ensues.

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