• Yuanqiang He, Yulong Zheng, Chuanqin Xu, Haichen Yang, Ziyu Wang, Liyang Zhou, Yufeng Wan, Donghui Zheng, and Jing Zhu.
• Department of Respiratory Medicine, Huai'an Hospital, Huai'an Second Hospital, Xuzhou Medical College, Huai'an, Jiangsu, China.
• Clin Respir J. 2016 May 1; 10 (3): 318-25.

BackgroundThere is a lack of randomized controlled trials to assess the effects of pharmacological treatments in patients with stable chronic obstructive pulmonary disease (COPD) complicated with moderate or severe depression.AimsTo assess the efficacy of sertraline hydrochloride on improving the quality of life of patients with stable COPD complicated with depression.MethodsThis randomized controlled trial, conducted from May to November 2013 in the Huai'an Second Hospital, Huai'an, China, enrolled 120 patients with stable COPD who had moderate or severe depression. Patients were randomly assigned to control and interventional groups (n = 60 in each group). In addition to the treatment for COPD, interventional group also received sertraline hydrochloride tablets 50 mg/day for 6 weeks, while the control group received placebo. The primary end point included COPD assessment test (CAT) scores and the secondary endpoint included 6-min walk distance and 17-item Hamilton Depression Rating Scale (HAMD-17) scores. Parameters of spirometry and adverse events were also observed.ResultsThere was no significant difference in improvements in the parameters of spirometry tests before and after the treatment with sertraline hydrochloride tablets between the placebo and interventional groups (P > 0.05). Patients in the sertraline hydrochloride group showed more changes in the HAMD-17 scores and CAT scores after treatment (P < 0.05) and travelled longer distances in the 6-min walk test than in the placebo group (P < 0.05).ConclusionAntidepressant treatment can improve the quality of life and exercise capacity of patients with depression, and it can also improve depression scores, but not lung function.© 2014 John Wiley & Sons Ltd.

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