• Yuji Ding, Shenmao Li, An'an Duan, Xiaoqian Yu, Yang Hua, Jiang Liu, Jiansheng Wang, Jiakang Cao, Ruilin Zhao, Geng Xu, Chun Gu, and Zhongpu Wang.
• Department of Neurosurgery, Xuan Wu Hospital, Capital University of Medical Sciences, Beijing 100053.
• Chin. Med. Sci. J. 2002 Jun 1; 17 (2): 85-9.

ObjectiveTo summarize the experience of minimally invasive treatment in 520 patients with intracranial aneurysms on a retrospective study.MethodsThe measures used in the treatment of 520 patients were reviewed in terms of timing of surgery, induced-hypotensive anesthesia, brain protection combined with temporal occlusion of the feeding artery, external drainage of CSF, dynamic monitoring of intracranial pressure, blood flow velocity, serum osmolality and CT scanning, anti-vasospasm therapy as well as selected interventional endovascular embolization of aneurysms.ResultsOf the 520 patients, 485 were treated with either direct clipping or endovascular embolization and 35 patients were treated non-surgically. In 449 patients undergoing direct clipping and 36 undergoing endovascular embolization, intraoperative rupture of aneurysm occurred in 27 (6.0%) and 0%, respectively. Death occurred in 13 (2.6%), hemiplegia in 8 (1.6%), and vegetative state in 2 (0.4%). The operative mortality of direct clipping was 3.8% in 210 patients before 1990 and 1.8% in 275 patients after 1990 (36 patients undergoing endovascular embolization, the operative mortality was 0%).ConclusionThe outcome of patients with intacranial aneurysms can be markedly improved and the operative mortality can be lowered by minimally invasive treatment.

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