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World J Pediatr Congenit Heart Surg · Jan 2015
Case ReportsPlasma exchange on venovenous extracorporeal membrane oxygenation with bivalirudin anticoagulation.
- Thomas J Preston, Heidi J Dalton, Kathleen K Nicol, Brit R Ferrall, Julie C Miller, and Don Hayes.
- Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA Heart Center, Nationwide Children's Hospital, Columbus, OH, USA Department of Cardiovascular Perfusion and ECMO, Nationwide Children's Hospital, Columbus, OH, USA thomas.preston@nationwidechildrens.org.
- World J Pediatr Congenit Heart Surg. 2015 Jan 1; 6 (1): 119-22.
AbstractA pediatric patient requiring venovenous (VV) extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation developed heparin-induced thrombocytopenia. Unfractionated heparin was discontinued, and a bivalirudin infusion was started. During the lung transplant evaluation, he was found to have allosensitization, requiring treatment with plasma exchange along with pulse methylprednisolone, rituximab, bortezomib, and pooled immunoglobulin infusion. We describe our experience with successful plasma exchange for allosensitization during bivalirudin anticoagulation on VV ECMO in a pediatric patient.© The Author(s) 2014.
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