• Int. J. Radiat. Oncol. Biol. Phys. · Sep 2010

    Performance of a novel repositioning head frame for gamma knife perfexion and image-guided linac-based intracranial stereotactic radiotherapy.

    • Mark Ruschin, Nazanin Nayebi, Per Carlsson, Kevin Brown, Messeret Tamerou, Winnie Li, Normand Laperriere, Arjun Sahgal, Young-Bin Cho, Cynthia Ménard, and David Jaffray.
    • Princess Margaret Hospital, Toronto, Canada. Mark.Ruschin@rmp.uhn.on.ca
    • Int. J. Radiat. Oncol. Biol. Phys. 2010 Sep 1; 78 (1): 306-13.

    PurposeTo evaluate the geometric positioning and immobilization performance of a vacuum bite-block repositioning head frame (RHF) system for Perfexion (PFX-SRT) and linac-based intracranial image-guided stereotactic radiotherapy (SRT).Methods And MaterialsPatients with intracranial tumors received linac-based image-guided SRT using the RHF for setup and immobilization. Three hundred thirty-three fractions of radiation were delivered in 12 patients. The accuracy of the RHF was estimated for linac-based SRT with online cone-beam CT (CBCT) and for PFX-SRT with a repositioning check tool (RCT) and offline CBCT. The RCT's ability to act as a surrogate for anatomic position was estimated through comparison to CBCT image matching. Immobilization performance was evaluated daily with pre- and postdose delivery CBCT scans and RCT measurements.ResultsThe correlation coefficient between RCT- and CBCT-reported displacements was 0.59, 0.75, 0.79 (Right, Superior, and Anterior, respectively). For image-guided linac-based SRT, the mean three-dimensional (3D) setup error was 0.8 mm with interpatient (Sigma) and interfraction (sigma) variations of 0.1 and 0.4 mm, respectively. For PFX-SRT, the initial, uncorrected mean 3D positioning displacement in stereotactic coordinates was 2.0 mm, with Sigma = 1.1 mm and sigma = 0.8 mm. Considering only RCT setups <1mm (PFX action level) the mean 3D positioning displacement reduced to 1.3 mm, with Sigma = 0.9 mm and sigma = 0.4 mm. The largest contributing systematic uncertainty was in the superior-inferior direction (mean displacement = -0.5 mm; Sigma = 0.9 mm). The largest mean rotation was 0.6 degrees in pitch. The mean 3D intrafraction motion was 0.4 +/- 0.3 mm.ConclusionThe RHF provides excellent immobilization for intracranial SRT and PFX-SRT. Some small systematic uncertainties in stereotactic positioning exist and must be considered when generating PFX-SRT treatment plans. The RCT provides reasonable surrogacy for internal anatomic displacement.Copyright (c) 2010 Elsevier Inc. All rights reserved.

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