• Biomarkers in medicine · Dec 2013

    Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation.

    • Burç Dedeoglu, Hilde R H de Geus, Gijs Fortrie, and Michiel G H Betjes.
    • Department of Nephrology, Erasmus University Medical Center, Rotterdam, The Netherlands.
    • Biomark Med. 2013 Dec 1; 7 (6): 947-57.

    AimBecause of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers.Materials & MethodsTwenty-six consecutive adult liver transplantations were evaluated. Markers were measured at four different time points during an intensive care unit admission.ResultsPlasma NGAL detected AKI with an optimal area under the curve at 8 h after admission (0.86; p = 0.004) and at 4 h after admission for urinary NGAL (0.80; p = 0.012). The other markers failed to detect AKI.ConclusionNGAL is a promising biomarker for detecting AKI in patients after liver transplantation.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…