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Expert Rev Neurother · Jan 2015
ReviewEffect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis.
- Sven G Meuth, Carlos Vila, and Kerry L Dechant.
- Department of Neurology, University of Münster, Albert-Schweitzer Campus 1, 48149 Münster, Germany.
- Expert Rev Neurother. 2015 Jan 1; 15 (8): 909-18.
AbstractIndividuals with multiple sclerosis (MS) spasticity may experience a range of symptoms, such as bladder dysfunction, pain, impaired sleep quality and mobility restrictions that worsen as spasticity severity increases. In this review, the effects of Sativex(®) oromucosal spray on symptoms and functional impairment associated with MS-related spasticity were examined. Across Sativex studies, there was a clear trend for improvement in spasticity-associated symptoms that was more pronounced and sustained over time in Sativex responders. Meaningful symptomatic improvement was achieved within the recommended dosage limit of ≤12 sprays per day. In appropriate patients, Sativex has the potential to minimize the consequences of spasticity-related symptoms on quality of life and reduce the economic burden on healthcare systems.
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