• N. Engl. J. Med. · Apr 2006

    Variant of hepatitis B virus with primary resistance to adefovir.

    • Oliver Schildgen, Hueseyin Sirma, Anneke Funk, Cynthia Olotu, Ulrike C Wend, Heinz Hartmann, Martin Helm, Jürgen K Rockstroh, Wulf R Willems, Hans Will, and Wolfram H Gerlich.
    • Institute of Medical Microbiology and Immunology and the Department of Medicine I, University of Bonn, Bonn, Germany.
    • N. Engl. J. Med. 2006 Apr 27; 354 (17): 1807-12.

    AbstractThe reverse-transcriptase inhibitor lamivudine (Zeffix, GlaxoSmithKline) is often used to treat chronic infection with hepatitis B virus (HBV) until resistance develops. Treatment may then be switched to the reverse-transcriptase inhibitor adefovir (Hepsera, Gilead), which has a lower frequency of resistance. Here, we describe three cases of primary adefovir resistance that were sensitive to tenofovir (Viread, Gilead). All three cases involved a rare HBV variant with a valine at position 233 of the reverse-transcriptase domain instead of isoleucine (rtI233V), as in the wild-type virus. This HBV variant also displayed resistance to adefovir and sensitivity to tenofovir in vitro.Copyright 2006 Massachusetts Medical Society.

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