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Rev Bras Ter Intensiva · Mar 2010
Understanding the PIRO concept: from theory to clinical practice - part 2.
- Maira de Moraes Rosolem, Lígia Sarmet Cunha Farah Rabello, Juliana Vassalo Leal, Márcio Soares, Thiago Lisboa, and Jorge Ibrain Figueira Salluh.
- Centro de Terapia Intensiva, Hospital do Câncer-I, Instituto Nacional do Câncer - INCA, Rio de Janeiro, RJ, Brasil.
- Rev Bras Ter Intensiva. 2010 Mar 1; 22 (1): 64-8.
AbstractA sepsis staging system focused on predisposition, insult, host response and organ failure may provide a useful basis for risk stratification. Knowledge on interactions among predisposing factors, insult characteristics and host response might help us to improve our understanding on sepsis pathophysiology and allow more individual therapeutic approach. Recent clinical studies documented the clinical importance of PIRO approach for severity stratification in septic patients in intensive care unit, and also for specific conditions such as community acquired pneumonia and ventilator associated pneumonia , with a good performance for outcome prediction. In this review we describe how this new concept can be used in clinical practice and provide some insights on its usefulness to facilitate the stratification and potential for enrollment in clinical trials of sepsis therapies.
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