• Z-H Li, Y-L Zhao, W Zhu, and G Yang.
• Department of Critical Care Medicine, Municipal Hospital affiliated to Xuzhou Medical College (Xuzhou First People's Hospital), Xuzhou, Jiangsu, China. zyliang0420@163.com.
• Eur Rev Med Pharmacol Sci. 2015 Aug 1; 19 (15): 2860-5.

ObjectiveTo investigate the clinical significance of mild hypothermia therapy in patients with resuscitation of cardiac arrest and analyze the possible molecular mechanism.Patients And MethodsNinety-six patients with successful resuscitation of cardiac arrest in ICU were hospitalized from June 2009 to July 2014. They were divided into a control group (n=37 cases) and an observation group (n=59 cases). All patients received high-grade life support treatment immediately after resuscitation. The treatment for the control group was combined with normal temperature treatment while the treatment for the observation group was combined with mild hypothermia therapy.Results1. Glasgow coma scale (GCS) scores of the patients in the two groups increased gradually after treatment as the APACHE II scores decreased. Comparisons within the group showed significant differences (p < 0.05). The GCS scores of the observation group were significantly increased compared to those in the control group, and the APACHE score decreased significantly. The differences between the groups were statistically significant (p < 0.05). 2. The serum lactic acid, sCD14, S100 β protein and TNF-a level of patients in two groups all decreased after treatment. The difference was statistically significant (p < 0.05 =. 3. The 24h and 7d survival rates of patients in the observation group are higher than that in the control group (p < 0.05).ConclusionsThe early treatment of hypothermia, can improve the outcome of patients with cardiac arrest.

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