• Marjan Joudi, Mehdi Fathi, Hadi Harati, Mitra Joudi, Azra Izanloo, Ali Rahdari, and Ghasem Soltani.
• Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
• Anesth Pain Med. 2014 Oct 1; 4 (4): e18545.

BackgroundCognitive disorder is a fluctuating cognitive destruction and a common problem for hospitalized patients, which leads to loss of consciousness. It is usually accompanied with increased mortality, prolonged hospital stay, and decreased rehabilitation.ObjectivesThe purpose of this study was to determine risk factors associated with cognitive disorder after open-heart surgery.Patients And MethodsIn total, 171 patients who had undergone off-pump open-heart surgery and lacked any history of psychiatric disorders were enrolled. Samples were selected according to a purposive sampling method. The Mini-Mental State Examination questionnaire was used for these patients to assess the incidence of cognitive disorder 24 hours after the operation in ICU and to compare creatinine level, ESR, extubation time and patients' age in the two groups, one with postoperative cognitive disorder and the other without it. Independent T-test was used to compare the two groups regarding any history of diseases such as diabetes, hypertension and hyperlipidemia, Chi square test was used.ResultsIn total, 75% of patients had postoperative cognitive disorder. There was a significant association between the history of high blood pressure, C-reactive protein and preoperative creatinine levels in both cognitive disorder and control groups.ConclusionsGiven the significant prevalence of postoperative cognitive disorder and significant associatio n between the history of high blood pressure, C-reactive protein and preoperative creatinine and cognitive disorder, detection of patient's clinical symptoms may improve diagnosis, treatment and prevention of this disorder.

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