• Hong Kong Med J · Apr 2015

    Review Case Reports

    Acquired factor V inhibitor in a patient receiving venous-venous extracorporeal membrane oxygenation for Legionella pneumonia.

    • Anne K H Leung, George W Y Ng, K C Sin, S Y Au, K Y Lai, K L Lee, and K I Law.
    • Intensive Care Unit, Queen Elizabeth Hospital, Jordan, Hong Kong.
    • Hong Kong Med J. 2015 Apr 1; 21 (2): 175-8.

    AbstractWe report a rare complication of factor V deficiency in a patient having Legionella pneumonia. This patient also had other complications like severe acute respiratory distress syndrome, acute kidney injury, and septic shock that required venous-venous extracorporeal membrane oxygenation support. This is the first reported case of acquired factor V deficiency in a patient receiving extracorporeal membrane oxygenation for Legionella pneumonia. With the combined use of intravenous immunoglobulin, rituximab and plasma exchange, we achieved rapid clearance of the factor V inhibitor within 1 week so as to allow safe decannulation of extracorporeal membrane oxygenation.

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