• Neuroscience letters · Mar 2003

    Evaluation of indices of skeletal muscle contraction in areas of referred hyperalgesia from an artificial ureteric stone in rats.

    • Maria Adele Giamberardino, Giannapia Affaitati, Rosanna Lerza, Giorgio Fanò, Stefania Fulle, Silvia Belia, Domenico Lapenna, and Leonardo Vecchiet.
    • Department of Medicine and Science of Aging, 'G D'Annunzio' University of, Chieti, Italy. mag@unich.it
    • Neurosci. Lett. 2003 Mar 6; 338 (3): 213-6.

    AbstractThis study examined indices of skeletal muscle contraction in a rat model of referred muscle hyperalgesia from artificial ureteric calculosis [left oblique muscle (OE) for ipsilateral stone]. In specimens from the left versus right OE of stone-implanted female rats, a significant increase was found in membrane fluidity (P<0.01) and Ca(2+)-ATPase activity (P<0.0001) and a significant decrease in 3H-ryanodine binding (P<0.0001) and in I band length/sarcomere length ratio (contraction index) (P<0.01). The increase in Ca(2+)-ATPase activity was directly and significantly related to the number of rats' ureteral 'crises' (P<0.02). The results indicate a state of contraction in the hyperalgesic muscle, whose extent correlates to the algogenic activity of the ureteral stone.

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