• Int J STD AIDS · Oct 2015

    Case Reports

    Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution.

    • Juri Katchanov, Cristiane Blechschmidt, Kirsten Nielsen, Gordian Branding, Keikawus Arastéh, Kathrin Tintelnot, Graeme Meintjes, David R Boulware, and Hartmut Stocker.
    • Department of Infectious Diseases and Gastroenterology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany juri.katchanov@icloud.com.
    • Int J STD AIDS. 2015 Oct 1; 26 (12): 912-4.

    AbstractWe report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.© The Author(s) 2015.

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