• Y Nancy You, Robert E Roses, George J Chang, Miguel A Rodriguez-Bigas, Barry W Feig, Rebecca Slack, Sa Nguyen, and John M Skibber.
• Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77230-4008, USA. ynyou@mdanderson.org
• Dis. Colon Rectum. 2012 Dec 1; 55 (12): 1213-9.

BackgroundLocal excision, alone or in combination with chemoradiation, is increasingly considered for rectal cancer. Higher risks of disease recurrence have been demonstrated after local excision.ObjectiveThe aim of this study was to examine the outcomes of current-era multimodality salvage for recurrent rectal cancer after local excision.DesignThis was a single-institutional retrospective study.SettingsThis study was conducted at a tertiary-referral cancer center between 1993 and 2011.PatientsForty-six patients with recurrent rectal cancer after initial local excision were included.InterventionMultimodality salvage treatment was performed as appropriate.Main Outcome MeasuresThe primary outcomes measured were the pattern of disease recurrence, salvage treatments, and resultant overall and re-recurrence-free survival.ResultsAfter the initial local excision, recurrent disease was diagnosed after a median interval of 1.9 years: local/regionally in 67%, distantly in 18%, and both in 15%. Four patients (9%) had recurrence that was unsalvageable, 2 (4%) declined treatment, and 40 (87%) underwent surgical salvage. Preoperative chemoradiation was given in 30 (75%) patients. The R0 resection rate was 80%, requiring multivisceral resection (33%), total pelvic exenteration (5%), and metastasectomy (25%). The rate of sphincter preservation was 33%, and perioperative morbidity was 50%. The first site of failure after salvage was distant in 38% and was local only in 10%. The 5-year overall and 3-year re-recurrence-free survival were 63% and 43%. Pathologic stage at initial local excision, receipt of neoadjuvant chemoradiation before local excision, recurrence pattern after local excision, pathologic stage at salvage, and R0 resection at salvage influenced re-recurrence-free survival.LimitationsThis study was limited by the referral and selection biases inherent in a small study cohort.ConclusionsFailure after local excision for rectal cancer may not be salvageable. When feasible, multimodality treatment, including multivisceral resection, pelvic irradiation, and chemotherapy, was associated with potentially lasting treatment-related morbidities and only modest success in long-term disease control. These findings should be compared with the expected stage-specific outcomes of standard proctectomy for early-stage rectal cancer, when local excision is being considered.

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