• Mauro Liberatore, Mario Barteri, Valentina Megna, Piera D'Elia, Stefania Rebonato, Augusto Latini, Francesca De Angelis, Francesca Anna Scaramuzzo, Maria Egle De Stefano, Noemi Antonella Guadagno, Sotirios Chondrogiannis, Anna Margherita Maffione, Domenico Rubello, Alessandro Pala, and Patrick M Colletti.
• From the Departments of *Radiological, Oncological, and Pathological Sciences, †Chemistry, ‡Gynecology, Obstetrics, and Urology, Laboratory of Biochemistry of Sexual Hormones, and §Anatomy, Histology, Forensic Medicine, and Orthopedics, Sapienza University of Rome; ∥Centre for Life Nano, Istituto Italiano di Tecnologia; ¶Department of Basic and Applied Sciences for Engineering, and **Department of Biology and Biotechnology, Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome; ††Department of Nuclear Medicine, PET Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy; and ‡‡Department of Radiology, University of Southern California, Los Angeles, CA.
• Clin Nucl Med. 2015 Feb 1; 40 (2): e104-10.

AbstractAmong the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.

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