• Masayoshi Kofune, Ichiro Watanabe, Kimie Ohkubo, Sonoko Ashino, Yasuo Okumura, Koichi Nagashima, Hiroaki Mano, Toshiko Nakai, Yuji Kasamaki, and Atsushi Hirayama.
• Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
• Int Heart J. 2011 Jan 1; 52 (5): 290-4.

AbstractThe right ventricular outflow tract (RVOT) is considered the arrhythmogenic region that gives rise to Brugada syndrome. To obtain a better understanding of this substrate, we performed electroanatomic mapping of the right ventricle (RV) in patients with Brugada syndrome. The RV was mapped electroanatomically with the CARTO system in 11 patients with asymptomatic Brugada syndrome but in whom ventricular fibrillation was induced by programmed ventricular stimulation, and in 5 control patients. The low voltage zone area (< 1.5 mV) was larger (16.1% versus 7.8%, P < 0.01) and the bipolar electrogram duration was greater (81.6 ± 7.8 ms versus 53.4 ± 5.6 ms, P < 0.01) in the patients with Brugada syndrome versus the control patients; the bipolar electrogram duration was greater in the septal portion and free wall of the RVOT. Our data suggest that regional endocardial conduction slowing based on structural abnormalities exists at the RVOT in Brugada syndrome.

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