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Emerg. Med. Clin. North Am. · Aug 2015
ReviewCardiotoxicodynamics: Toxicity of Cardiovascular Xenobiotics.
- Nathan B Menke, Steven J Walsh, and Andrew M King.
- Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh Medical Center, 3600 Forbes Avenue, Iroquois Building, Suite 402, Pittsburgh, PA 15213, USA. Electronic address: menkenb@upmc.edu.
- Emerg. Med. Clin. North Am. 2015 Aug 1;33(3):563-95.
AbstractMaintaining adequate tissue perfusion depends on a variety of factors, all of which can be influenced by xenobiotics (substances foreign to the body, including pharmaceuticals, chemicals, and natural compounds). Volume status, systemic vascular resistance, myocardial contractility, and cardiac rhythm all play a significant role in ensuring hemodynamic stability and proper cardiovascular function. Direct effects on the nervous system, the vasculature, or the heart itself as well as indirect metabolic effects may play a significant role in the development of cardiotoxicity. This article is dedicated to discussion of the disruption of cardiovascular physiology by xenobiotics.Copyright © 2015 Elsevier Inc. All rights reserved.
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