• Manuel Held, Afshin Rahmanian-Schwarz, Jennifer Schiefer, Rebekka Rath, Jan-Ole Werner, Shahab Rahmanian, Hans-Eberhard Schaller, and Wiebke Petersen.
• *Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Germany; †Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, HELIOS Klinikum Wuppertal GmbH, University Hospital Witten/Herdecke, Germany.
• Dermatol Surg. 2016 Jun 1; 42 (6): 751-6.

BackgroundToday, autologous skin transplantation is frequently used for full-thickness skin defects. There is still a high demand for new wound-healing products to replace autologous skin transplantation.ObjectiveIn this context, the effect of a new collagen-gelatin scaffold on full-thickness skin defects was evaluated.Materials And MethodsFour full-thickness skin defects were created surgically on the dorsum of 6 Göttingen minipigs. Three wounds were randomly treated with a novel collagen-gelatin scaffold in different thicknesses, whereas the fourth wound was left untreated and served as a control wound. During the experimental period of 21 days, a close-up photographic documentation was performed. Afterwards, the areas of the initial wounds were excised and examined histologically.ResultsThe systematic evaluation of 24 wounds showed that treatment with the new collagen-gelatin scaffold led to an accelerated wound repair of 1.1 days. Compared to control wounds, it also demonstrated improved skin quality in regard to epidermal thickness.ConclusionThe new collagen-gelatin scaffold supports and accelerates dermal wound repair compared to untreated control wounds. Nevertheless, wound treatment with the scaffold was only performed on the first day. In further studies, the impact of multiple scaffold applications on full-thickness skin defects should be investigated.

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