• Proc. Soc. Exp. Biol. Med. · May 1989

    Increased plasma levels of platelet-derived growth factor activity in patients with progressive systemic sclerosis.

    • A Pandolfi, M Florita, G Altomare, P Pigatto, M B Donati, and A Poggi.
    • Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy.
    • Proc. Soc. Exp. Biol. Med. 1989 May 1; 191 (1): 1-4.

    AbstractWe measured mitogenic activity of whole blood serum and platelet-poor plasma-derived serum of a group of 10 patients with progressive systemic sclerosis and of 8 controls. Mitogenic activity of plasma-derived serum was greater in patients than in controls, in the absence of other signs of platelet activation. This increased activity was inhibited by specific antibodies, anti-platelet derived growth factor, suggesting that circulating levels of platelet-derived growth factor may be present in progressive systemic sclerosis patients. Platelet-derived growth factor, released either by platelets or by monocytes, might play a role in the pathogenesis of scleroderma.

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