• Stroke · Feb 2007

    Review

    Imaging inflammation in acute brain ischemia.

    • Sebastian Jander, Michael Schroeter, and Andreas Saleh.
    • Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany. jander@uni-duesseldorf.de
    • Stroke. 2007 Feb 1; 38 (2 Suppl): 642-5.

    AbstractBrain inflammation holds promise as a therapeutic target in subacute stages of ischemic stroke. At the cellular level, postischemic inflammation is dominated by cells of the innate immune system with resident microglia/brain macrophages and blood-derived monocytes/macrophages being the most important cell types involved. Iron oxide nanoparticles such as ultrasmall superparamagnetic iron oxide (USPIO) are novel cell-specific contrast agents for MRI. After intravenous injection USPIO is taken up by circulating phagocytic cells. USPIO-laden macrophages cause typical signal changes in MRI of infarcted brain parenchyma, which has been demonstrated in studies of both experimental ischemia and human stroke. USPIO-enhanced MRI may therefore represent an important tool to address the role of macrophages for ischemic lesion development both in basic science and clinical studies.

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