• Best Pract Res Clin Gastroenterol · Apr 2012

    Review

    Role of ASA in the primary and secondary prevention of cardiovascular events.

    • Rubén Casado-Arroyo, Fatih Bayrak, Andrea Sarkozy, Gian-Battista Chierchia, Carlo de Asmundis, and Pedro Brugada.
    • Heart Rhythm Management Center, Cardiovascular Center, Free University of Brussels (UZ Brussel) VUB, Brussels, Belgium. rbcasado@gmail.com
    • Best Pract Res Clin Gastroenterol. 2012 Apr 1; 26 (2): 113-23.

    AbstractCardiovascular disease, which includes coronary heart disease, cerebrovascular disease and peripheral artery disease, is the leading cause of death in developed countries. Evidence from basic research, clinical investigations, observational epidemiologic studies and randomized clinical trials has provided strong support for the benefits of aspirin in decreasing the risk of cardiovascular events in a wide range of pathologies in secondary prevention. Data in primary prevention have far more uncertainties. An overview for the evidence supporting the efficacy of aspirin in primary and secondary prevention of cardiovascular disease is discussed, including the relative and absolute benefit and the risks of side effects. Finally, future developments in the field directed towards individualized treatment strategies and novel antiplatelet agents are examined.Copyright © 2012 Elsevier Ltd. All rights reserved.

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