• Parkinsonism Relat. Disord. · Dec 2011

    Review Meta Analysis

    Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.

    • Daan C Velseboer, Rob J de Haan, Wouter Wieling, David S Goldstein, and Rob M A de Bie.
    • Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
    • Parkinsonism Relat. Disord. 2011 Dec 1; 17 (10): 724-9.

    BackgroundAlthough orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature.MethodsFrom PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis.ResultsWe found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses.ConclusionsThe estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.Copyright © 2011 Elsevier Ltd. All rights reserved.

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