• Medical hypotheses · Jan 2016

    Perioperative use of centrally acting angiotensin-converting enzyme inhibitor may increase patients' risk for postoperative nausea and vomiting.

    • Chao Xiong, Liting Wang, Dongjiao An, Meijiang Lu, Wenzhen Shen, Yun Wang, Yun Yue, and Anshi Wu.
    • Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
    • Med. Hypotheses. 2016 Jan 1; 86: 1-2.

    AbstractSubstance P (SP) is involved in the development of postoperative nausea and vomiting (PONV). It is hydrolyzed by angiotensin-converting enzyme (ACE). Centrally acting ACE inhibitors (CACE-Is) are widely used in the perioperative period. The current evidence showed CACE-Is could upregulate SP level in the central nervous system which may contribute to the occurrence of PONV in 0-72 h. Here, we present our hypothesis that the use of CACE-Is in the perioperative period may increase patients' risk for both early (0-24h) and late (24-72 h) PONV. The identification of this new risk factor may improve patients' risk assessment and thus lead to better prophylaxis strategies for PONV that are base on risk stratification.Copyright © 2015 Elsevier Ltd. All rights reserved.

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