• Vet Hum Toxicol · Dec 2000

    Case Reports

    Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.

    • R J Roberge, P Rao, G R Miske, and T J Riley.
    • Department of Emergency Medicine, St Francis Medical Center, Pittsburgh, PA 15201, USA.
    • Vet Hum Toxicol. 2000 Dec 1; 42 (6): 351-3.

    AbstractWe present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy. Cholestyramine was utilized to interrupt the enterohepatic recycling of warfarin and for its antidiarrheal effects to prevent gastrointestinal vitamin K wasting. Cholestyramine enabled the use of very low doses of sc vitamin K1 (2 mg total) with subsequent attainment of a therapeutic International Normalized Ratio in 39 h.

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