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Case Reports
[Paraneoplastic neurological syndrome in 64-year-old patient in association with a small cell lung carcinoma].
- Z Prouzová and S Brychtová.
- Ustav klinicke a molekularni patologie LF UP a FN Olomouc. zuzana.prouzova@fnol.cz
- Klin Onkol. 2012 Jan 1; 25 (6): 471-5.
BackgroundParaneoplastic neurological syndromes are rare conditions manifest as psychiatric/neurological symptoms. They are caused by autoimmunne cross-reaction leading to destruction of the central nervous system.CaseWe present the case of a 64-year-old patient hospitalized for 6 months at the Department of Psychiatry for persisting depression. During that time he progressed to delirium. A diagnosis of diffuse encephalopathy was made, but further examination revealed a small cell lung cancer with generalisation. A paraneoplastic syndrome was finally diagnosed after autoptic and histologic examination.ConclusionParaneoplastic neurological syndromes can be early signs of malignancy and may considerably precede oncologic diagnosis.
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