• Daniel P Bailey and Christopher D Locke.
• University of Bedfordshire, Institute for Sport and Physical Activity Research, Department of Sport Science and Physical Activity, UK. Electronic address: daniel.bailey@beds.ac.uk.
• J Sci Med Sport. 2015 May 1; 18 (3): 294-8.

ObjectivesTo explore the effects of breaking up prolonged sitting time with standing or light-intensity walking on a range of cardiometabolic risk markers.DesignA randomised three-period, three-treatment acute crossover trial.MethodsTen non-obese adults took part in three trials: (1) uninterrupted sitting; (2) seated with 2-min bouts of standing every 20 min; and (3) seated with 2-min bouts of light-intensity walking every 20 min. Two standardised test drinks (total 80.3 carbohydrate, 50 g fat) were provided after an initial 1-h period of uninterrupted sitting. Plasma glucose and blood pressure were assessed hourly to calculate area under the curve. Total cholesterol, HDL, and triglycerides were assessed at baseline and 5-h. ANOVAs were used to explore between-trial differences.ResultsGlucose area under the curve was lower in the activity-break condition compared to the uninterrupted sitting and standing-break conditions: mean area under the curve 18.5 (95% CI 17, 20), 22.0 (20.5, 23.5), and 22.2 (20.7, 23.7) mmol L/5-h, respectively, p<0.001; no difference between uninterrupted sitting and standing-break conditions (p>0.05). Systolic and diastolic blood pressure area under the curve did not differ significantly between conditions, nor did responses in lipid parameters (p>0.05).ConclusionsThis study suggests that interrupting sitting time with frequent brief bouts of light-intensity activity, but not standing, imparts beneficial postprandial responses that may enhance cardiometabolic health. These findings may have importance in the design of effective interventions to reduce cardiometabolic disease risk.Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

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