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Acta Anaesthesiol Belg · Jan 2013
ReviewIs there a rationale for an anesthesiologist's role against cancer recurrence?
- P Forget, P G Coulie, M Retsky, R Demicheli, J P Machiels, and M De Kock.
- Department of Anesthesiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. forgetpatrice@yahoo.fr
- Acta Anaesthesiol Belg. 2013 Jan 1; 64 (1): 15-24.
AbstractGrowth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and acceleration of tumor growth. Understanding the role of inflammation and its consequences (i.e., immune response, growth factors, dissemination of tumor cells) could lead to define a role of anesthesiologists in reducing cancer recurrence following surgery. We argue for peri-operative pharmacological interventions to reduce cancer relapse, with a focus on non-steroidal anti-inflammatory drugs.
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