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Cahiers d'anesthésiologie · Jan 1994
[Mechanisms of the analgesic effect of alpha 2 adrenergic agonists].
- F Bonnet.
- Service d'Anesthésie Réanimation, Hôpital-Henri Mondor, Créteil.
- Cah Anesthesiol. 1994 Jan 1; 42 (6): 723-5.
AbstractAlpha 2 adrenergic agonists stimulate specific receptors in the dorsal horn of the spinal cord leading to blockade of potassium and calcium channels. Presynaptic alpha 2 receptors inhibit the release of substance P and other neuropeptides which stimulate transmission of nociceptive stimulations. Post-synaptic alpha 2 receptors hyperpolarize neurons membranes and decrease the activity of nociceptive neurons. In addition, alpha 2 adrenergic agonists have a synergistic action with opioid and cholinergic agonists.
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