• Br J Anaesth · May 1992

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Efficacy of orally administered ondansetron in the prevention of postoperative nausea and vomiting: a dose ranging study.

    • G N Kenny, J D Oates, J Leeser, D J Rowbotham, H Lip, M Rust, P Saur, M Onsrud, and C G Haigh.
    • Department of Anaesthesia, University of Glasgow.
    • Br J Anaesth. 1992 May 1; 68 (5): 466-70.

    AbstractIn a placebo-controlled, double-blind study, we have compared the efficacy of ondansetron 16 mg, 8 mg and 1 mg administered 8-hourly for prevention of postoperative nausea and vomiting. We studied 995 patients undergoing major gynaecological surgery; 982 were included in the analysis. Study medication was administered 1 h before induction of anaesthesia and second and third doses were given 8 and 16 h after the first. The treatment groups were similar for patient characteristics, surgical procedures, anaesthetics administered and opioids given. The frequency of nausea was 75%, 70%, 56% and 55% after placebo and ondansetron 1 mg, 8 mg and 16 mg, respectively; the corresponding frequencies of vomiting were 60%, 55%, 37% and 37%. Ondansetron 8 mg was as effective as 16 mg and both resulted in significant reductions in nausea and vomiting compared with placebo and ondansetron 1 mg (P less than 0.001).

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