• Pain Pract · Jun 2005

    Pregabalin for pain management.

    • Noor M Gajraj.
    • Baylor University Medical Center, Frisco, Texas, USA. noorgajraj@aol.com
    • Pain Pract. 2005 Jun 1; 5 (2): 95-102.

    AbstractPregabalin is a new analog of the neurotransmitter gamma-aminobutyric acid (GABA). It is an alpha2-delta (alpha2-delta) ligand that has analgesic, anticonvulsant, and anxiolytic activity. Alpha2-delta is an auxiliary protein associated with voltage-gated calcium channels. Pregabalin binds potently to the alpha2-delta subunit resulting in modulation of calcium channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P. This review discusses the pharmacology of this medication as well as available studies in patients.

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