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Anaesth Intensive Care · Dec 1997
Case ReportsSystemic levels of 6-keto-prostaglandin F1 alpha following administration of inhaled aerosolized prostacyclin.
- P V van Heerden.
- Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, W.A.
- Anaesth Intensive Care. 1997 Dec 1; 25 (6): 701-3.
AbstractA case is described where systemic levels of prostacyclin metabolite were measured during inhaled aerosolized prostacyclin (IAP) therapy for severe hypoxaemia in a patient with the acute respiratory distress syndrome. Comparable levels of prostacyclin metabolite have been associated with a marked platelet aggregation defect in vitro. A platelet aggregation defect was also demonstrated in vivo in this patient. Haemodynamic and gas exchange data during the IAP therapy are described.
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