• Gastroenterol. Clin. North Am. · Sep 2010

    Review

    Pharmacologic management of chronic constipation.

    • Siddharth Singh and Satish S C Rao.
    • Division of Gastroenterology/Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, 4612 JCP, Iowa City, IA 52242, USA.
    • Gastroenterol. Clin. North Am. 2010 Sep 1; 39 (3): 509-27.

    AbstractChronic constipation is a common digestive problem in North America, with significant psychosocioeconomic implications. Dietary and lifestyle measures and low-cost traditional over-the-counter laxatives are usually the first line of therapy but help only half of the patients. Several newer agents that act by increasing colonic peristalsis, altering colonic secretion, and/or antagonizing enteric opioid receptors have been developed that are effective in treating constipation and its related symptoms as well as improving quality of life. This article focuses on the pharmacology of traditional and newer agents for the treatment of constipation.Copyright © 2010 Elsevier Inc. All rights reserved.

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