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- Hiroshi Katsuki, Shingo Tateyama, Nami Hidaka, Takeshi Yano, Shoichiro Ibusuki, and Mayumi Takasaki.
- Department of Anesthesiology, Miyazaki Shigun Ishikai Hospital, Miyazaki 880-0834.
- Masui. 2004 Sep 1; 53 (9): 994-7.
BackgroundThe effect of glucose on local anesthetic-induced neural damage has not been fully studied. We examined the effect of glucose on hemolysis induced by local anesthetics.MethodsThe mean EC50 values (the local anesthetic level that causes destruction of half of the red blood cells in vitro) of lidocaine HCl, tetracaine HCl and dibucaine HCl were determined with 0% and 7.5% glucose contained in Krebs solution at pH 6.4.ResultsThe mean EC50 values of lidocaine HCl, tetracaine HCl, and dibucaine HCl in 0%-glucose Krebs solution were 6.51%, 0.45%, 0.17%, respectively, which increased significantly to 7.05%, 0.64% and 0.23%, in 7.5% glucose Krebs solution at pH 6.4.ConclusionsGlucose may have a protective role in local anesthetic-induced neural damage.
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