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- Giuseppe Gheno, Carmelo Savarino, Sandro Vellar, and Leonardo Cinetto.
- Departimento di Medicina Interna, Ospedale Civile di Asiago, ASL 3 Regione Veneto di Bassano del Grappa (VI). giuseppe.gheno@tin.it
- Ann. Ital. Med. Int. 2002 Jan 1; 17 (1): 51-3.
AbstractHyperkalemia may occur in many clinical settings and lead to serious events. Heparin-induced hyperkalemia is presumably less well recognized than other untoward effects of heparin treatment and more frequent than commonly perceived. To draw attention to this clinically relevant occurrence, we report 2 cases of life-threatening bradyarrhythmia associated with heparin prescription. Heparin-induced hyperkalemia is mediated by an enzymatic block in the synthesis of aldosterone; however, in most cases severe hyperkalemia occurs in the presence of additional factors influencing potassium homeostasis. Patients treated with heparin should be stratified and adequately monitored according to the outlined risk profile.
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